Matrix Metalloproteinase Expression and Inhibition After Sciatic Nerve Axotomy
نویسندگان
چکیده
منابع مشابه
Deprenyl changes the expression of Trk-B and P75 NTR receptors in rat after sciatic nerve axotomy
During development many of neurons die by the phenomenon named programmed cell death or apoptosis and this reaction is regulated by neurotrophin (BDNF, NGF, NT3 and NT4/5). These neurotrophins bind to two different classes of transmembrane receptor proteins, the Trks and P75 NTR. Axotomy can induce apoptosis after birth and deprenyl is a an inhibitor of monoamineoxidase type-B and seems to act ...
متن کاملDeprenyl changes the expression of Trk-B and P75 NTR receptors in rat after sciatic nerve axotomy
During development many of neurons die by the phenomenon named programmed cell death or apoptosis and this reaction is regulated by neurotrophin (BDNF, NGF, NT3 and NT4/5). These neurotrophins bind to two different classes of transmembrane receptor proteins, the Trks and P75 NTR. Axotomy can induce apoptosis after birth and deprenyl is a an inhibitor of monoamineoxidase type-B and seems to act ...
متن کاملDeprenyl increases synaptophysin and choline acetyltransferase in rat after sciatic nerve axotomy
Neuroprotective effect of deprenyl on motoneurons of spinal cord after axotomy of peripheral nerves such as sciatic has been well established. Deprenyl is an inhibitor of monoamine oxidase type-B (MAO-B). The main function of this agent is the release of neurotransmitters from pre-synaptic terminals. Acetylcholine is a neurotransmitter that is synthesized by choline acetyltransferase (ChAT) and...
متن کاملDeprenyl increases synaptophysin and choline acetyltransferase in rat after sciatic nerve axotomy
Neuroprotective effect of deprenyl on motoneurons of spinal cord after axotomy of peripheral nerves such as sciatic has been well established. Deprenyl is an inhibitor of monoamine oxidase type-B (MAO-B). The main function of this agent is the release of neurotransmitters from pre-synaptic terminals. Acetylcholine is a neurotransmitter that is synthesized by choline acetyltransferase (ChAT) and...
متن کاملDifferential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve
The neurotrophin family includes NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Previous studies have demonstrated that expression of NGF and its low-affinity receptor is induced in nonneuronal cells of the distal segment of the transected sciatic nerve suggesting a role for NGF during axonal regeneration (Johnson, E. M., M. Taniuchi, and P. S. ...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2001
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/60.1.85